Genetics of Ovarian Cancer

Andrew Shelling

Ovarian cancer is extremely difficult to detect, as there are usually no signs or symptoms until it has reached advanced stages. About 2% of women will develop ovarian cancer during their lifetime – often after age 50, but younger women are also affected. Younger women often become infertile if their ovaries or other reproductive organs are removed to treat the cancer. This can be devastating for women who have not yet had children and are now forced to live with infertility – and the fear of cancer returning.

Because ovarian cancer is often diagnosed at advanced stages, treatments to prolong life and protect fertility are limited. Dr Andrew Shelling is leading a study to understand the genetic changes that take place as the disease progresses, with the aim of identifying early warning signs of ovarian cancer. This research will lead to new treatments for early stages of ovarian cancer, increasing the chances of survival and the opportunity for younger women to retain their fertility.